This book constitutes the refereed proceedings of the 4th Symposium of the Norwegian AI Society, NAIS 2022, held in Oslo, Norway, during May 31-June 1, 2022. The 11 full papers included in this book were carefully reviewed and selected from 17 submissions. They were organized in topical sections as follows: robotics and intelligent systems; ai in cyber and digital sphere; ai in biological applications and medicine; and towards new ai methods.