This book covers virtually all aspects of the rapidly developing field of beta secretase (BACE), from the original isolation and cloning of BACE, to the discovery of various classes of BACE inhibitors, to challenges in clinical development. This 360 degree resource provides every member of the diverse drug-discovery team with global understanding essential for productive and successful drug discovery. It also offers researchers and clinicians an overview of the groundbreaking progress that has been made to develop inhibitors of BACE as efficacious treatments for Alzheimer's disease.