In this richly illustrated book, the contributors describe the Mereon Matrix, its dynamic geometry and topology. Through the definition of eleven First Principles, it offers a new perspective on dynamic, whole and sustainable systems that may serve as a template information model. This template has been applied to a set of knowledge domains for verification purposes: pre-life-evolution, human molecular genetics and biological evolution, as well as one social application on classroom management.The importance of the book comes in the following ways: