This book offers real-world data science and algorithm design topics linked to systems and software engineering. Furthermore, articles describing unique techniques in data science, algorithm design, and systems and software engineering are featured.This book is the second part of the refereed proceedings of the 6th Computational Methods in Systems and Software 2022 (CoMeSySo 2022). The CoMeSySo 2022 conference, which is being hosted online, is breaking down barriers. CoMeSySo 2022 aims to provide a worldwide venue for debate of the most recent high-quality research findings.