The book constitutes proceedings of the International Conference on Intelligent Systems and Human-Machine Collaboration 2022. The papers consist of research from different domains of human-machine interaction, computer engineering like quantum computational intelligence, big data analytics, the Internet of things, etc. The book includes significant contributions from academia and industry dealing with human-machine interaction both from the theoretical development and the application point of view. It also brings out research articles in interdisciplinary platforms applying human-machine interaction. The book is useful to researchers and practitioners alike.