This book constitutes revised selected papers from the 17th International Meeting on Computational Intelligence Methods for Bioinformatics and Biostatistics, CIBB 2021, which was held virtually during November 15-17, 2021.The 19 papers included in these proceedings were carefully reviewed and selected from 26 submissions, and they focus on bioinformatics, computational biology, health informatics, cheminformatics, biotechnology, biostatistics, and biomedical imaging.