This book constitutes the proceedings of the 5th International Conference on Blockchain, ICBC 2022, held as part of the Services Conference Federation, SCF 2022, held in Honolulu, HI, USA, in December 2022. The 8 full papers and 1 short paper presented in this volume were carefully reviewed and selected from 22 submissions.The International Conference on Blockchain (ICBC) aims to provide an international forum for both researchers and industry practitioners to exchange the latest fundamental advances in the state-of-the-art technologies and best practices of blockchain, as well as emerging standards and research topics which would define the future of blockchain.