This book constitutes the refereed proceedings of the 35th Australasian Joint Conference on Artificial Intelligence, AI 2022, which took place in Perth, WA, Australia, in December 5-8, 2022. The 56 full papers included in this book were carefully reviewed and selected from 90 submissions. They were organized in topical sections as follows: Computer Vision; Deep Learning; Ethical/Explainable AI; Genetic Algorithms; Knowledge Representation and NLP; Machine Learning; Medical AI; Optimization; and Reinforcement Learning.