Old vampires, roused from deep slumber in the earth, are doing the bidding of a Voice commanding that they indiscriminately burn their kin in cities across the globe, from Paris to Mumbai, Hong Kong to San Francisco. Left with little time to spare, a host of familiar characters including Louis de Pointe du Lac, Armand, and even the vampire Lestat, must embark on a journey to discover who--or what--is driving this mysterious being.