The essays collected here represent Robert D. Denham's longstanding interest in the expansive body of literary and cultural criticism of Northrop Frye, among the preeminent humanists of the twentieth century. The essays in part I, which date from 1992 to 2004, focus on Frye's late work with its decidedly religious thrust. These essays take full advantage of Frye's previously unpublished writing, especially his notebooks, now a part of his thirty-volume Collected Works. Part II centers on issues arising from Anatomy of Criticism, arguably the most important work of literary theory of the previous century. Part III is a miscellany. The essays here are devoted to Frye's life, his influence a half century after Anatomy of Criticism, and his views on medicine, Shakespeare, and education.