Iodine regulates nutritional metabolism probably via the microbiota. Thyrodiabetes has been of concern to clinicians. The endocrine disruptors came to remind us if need be that the thyroid gland is a sentinel of the environment which according to our approach testifies to the primordial role of mineral iodine in most living organisms. General conclusion : The Basténie classification is a bioclinical semiology which could be reviewed by integrating obesity as an incipiens stage of the epigenetic thyroid turn over of the deiodase realizing an inactive TSH. Primary hypothyroidism from a historical-technical point of view has been recognized since Bastenia:1 myxedema by thyroid atrophy with low T4 and T3 and high TSH.2 crude hypothyroidism or only elevated TSH.3 subclinical hypothyroidism or only TRH test is positive.4 thyroiditis or only autoantibodies exist 5 or turn over of the deiodase is involved.These are the perspectives of a practitioner in the medical clinic ward and endocrine diseases.

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