The COVID-19 pandemic and overlapping global crises, including geopolitical conflict and climate change, have made achievement of the United Nations Sustainable Development Goals (SDGs) more challenging. The scientific community incre-singly recognizes the need to accelerate the adoption of evidence-based, scientifically-sound policies and actions to operationalize sustainable development.This report identifies key research priorities and possible actionable steps to operationalize sustainable development at the global and local levels. Although the scope of the challenges and opportunities are global with many research investigations and actions needed, Operationalizing Sustainable Development to Benefit People and the Planet presents research priorities and possible actionable steps for consideration by U.S. stakeholders.Table of ContentsFront MatterExecutive Summary1 Introduction2 Education and Capacity Building3 Localization of the Sustainable Development Goals and IndigenousKnowledge4 Food Systems5 Urbanization6 Decarbonization7 Science, Technology, and Innovation for the SustainableDevelopment Goals8 Science and Peace9 Financing to Achieve the Sustainable Development Goals10 Moving ForwardReferencesAppendix A: Committee on Operationalizing Sustainable Development:Biographical InformationAppendix B: Workshop AgendasAppendix C: Biographies of Workshop Speakers