PART I: Introduction, selection, mechanisms. 1. Cell-penetrating peptides Matjaž Zorko and Ülo Langel 2. Shuttling homeoproteins and their biological significance Alain Prochiantz and Ariel Di Nardo 3. Artificial evolutionary optimization process to improve the functionality of CPPs Niels Röckendorf, Katrin Ramaker, and Andreas Frey 4. In silico design of chemically modified cell penetrating peptides Vinod Kumar, Gajendra Pal Singh Raghava 5. Synthetic Molecular Evolution of Cell Penetrating Peptides William C. Wimley 6. A native CPP from rattlesnake with therapeutic and theranostic properties Lucas C. Porta, Joana D'Arc Campeiro, and Mirian A. F. Hayashi 7. Synthesis of cell-penetrating peptide coated silica nanoparticles and their physicochemical and biological characterization Isabel Gessner, Annika Klimpel and Ines Neundorf 8. Enhancing the therapeutic potential of extracellular vesicles using peptide technology Carla Martin-Perez, Mariana Conceição, Richard Raz, Matthew J. A. Wood, and Thomas C. Roberts 9. Challenges and methods for the study of CPP translocation mechanisms Astrid Walrant, Françoise Illien, Sandrine Sagan, and Nicolas Rodriguez 10. Membrane molecular interactions and induced structures of CPPs Fatemeh Madani and Astrid Gräslund 11. A single GUV method for revealing the action of cell-penetrating peptides in biomembranes Md. Mizanur Rahman Moghal, Madhabi Lata Shuma, Md. Zahidul Islam, and Masahito Yamazaki 12. Methods for Small-Angle Scattering Measurements on Peptiplexes of DNA with Cell-Penetrating Peptides Emerson R.Silva, Lucas R. Mello, and Ian Hamley 13. Imaging CPP delivery mechanisms of oligonucleotides Najoua El Boujnouni, Alexander H. van Asbeck, Jürgen Dieker, Derick G. Wansink, and Roland Brock 14. Quantitative subcellular analysis of cyclic cell-penetrating peptide EJP18 in non-adherent cells Edward J. Sayers, Victoria L. Barlow, Yu-Hsuan Tsai, and Arwyn T. Jones 15. PepFect14: signaling and transfection Luca Falato, Maxime Gestin, and Ûlo Langel 16. Utilisation of cell-penetrating peptides for in vivo delivery of bioactive cargo - the effect of nanoparticle formulation Piret Arukuusk, Heleri Heike Härk, and Ülo Langel Part II: Delivery of proteins and protein mimics. 17. Protein delivery by PTDs/CPPs Caroline Palm-Apergi and Steve F. Dowdy 18. Protein Delivery to Cytosol by Cell-Penetrating Peptide Bearing a Tandem Repeat Penetration-Accelerating Sequence Akiko Okuda and Shiroh Futaki 19.Recombinant transcription factors (TFs) fused to ZEBRA minimal transduction domain (MD) for modulation of mRNA transcripts. Benjamin Caulier, Jean-Luc Lenormand, and David Laurin 20. Protein mimicry and the design of bioactive cell penetrating peptides: The genesis of STOPSPERM bioportides John Howl*, Joana Vieira Silva,, Margarida Fardilha, and Sarah Jones 21. Lipopeptide pepducins as therapeutic agents Emily Michael, Lidija Covic, and Athan Kuliopulos 22. Delivery of Antibiotics by Cell-Penetrating Peptides to Kill Intracellular Pathogens Christian Rüter 23. CPP applications in immune modulation and disease therapy Ja-Hyun Koo, Won-Ju Kim, and Je-Min Choi Part III: Targeting

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