This book gathers best selected research papers presented at the International Conference on Networking, Intelligent Systems and Security, held in Kenitra, Morocco, during 01-02 April 2021. The book highlights latest research and findings in the field of ICT, and it provides new solutions, efficient tools, and techniques that draw on modern technologies to increase urban services. In addition, it provides a critical overview of the status quo, shares new propositions, and outlines future perspectives in networks, smart systems, security, information technologies, and computer science.