This book constitutes the refereed proceedings of the 6th International Conference on Computer, Communication, and Signal Processing, ICCSP 2022, held in Chennai, India, in February 2022.*The 21 full and 2 short papers presented in this volume were carefully reviewed and selected from 111 submissions. The papers are categorized into topical sub-headings: artificial intelligence and machine learning; Cyber security; and internet of things.*The conference was held as a virtual event due to the COVID-19 pandemic.